Generative AI technologies, particularly Large Language Models (LLMs), have transformed information management systems but introduced substantial biases that can compromise their effectiveness in informing business decision-making. This challenge presents information management scholars with a unique opportunity to advance the field by identifying and addressing these biases across extensive applications of LLMs. Building on the discussion on bias sources and current methods for detecting and mitigating bias, this paper seeks to identify gaps and opportunities for future research. By incorporating ethical considerations, policy implications, and sociotechnical perspectives, we focus on developing a framework that covers major stakeholders of Generative AI systems, proposing key research questions, and inspiring discussion. Our goal is to provide actionable pathways for researchers to address bias in LLM applications, thereby advancing research in information management that ultimately informs business practices. Our forward-looking framework and research agenda advocate interdisciplinary approaches, innovative methods, dynamic perspectives, and rigorous evaluation to ensure fairness and transparency in Generative AI-driven information systems. We expect this study to serve as a call to action for information management scholars to tackle this critical issue, guiding the improvement of fairness and effectiveness in LLM-based systems for business practice.

Lung ultrasound is a growing modality in clinics for diagnosing and monitoring acute and chronic lung diseases due to its low cost and accessibility. Lung ultrasound works by emitting diagnostic pulses, receiving pressure waves and converting them into radio frequency (RF) data, which are then processed into B-mode images with beamformers for radiologists to interpret. However, unlike conventional ultrasound for soft tissue anatomical imaging, lung ultrasound interpretation is complicated by complex reverberations from the pleural interface caused by the inability of ultrasound to penetrate air. The indirect B-mode images make interpretation highly dependent on reader expertise, requiring years of training, which limits its widespread use despite its potential for high accuracy in skilled hands. To address these challenges and democratize ultrasound lung imaging as a reliable diagnostic tool, we propose LUNA, an AI model that directly reconstructs lung aeration maps from RF data, bypassing the need for traditional beamformers and indirect interpretation of B-mode images. LUNA uses a Fourier neural operator, which processes RF data efficiently in Fourier space, enabling accurate reconstruction of lung aeration maps. LUNA offers a quantitative, reader-independent alternative to traditional semi-quantitative lung ultrasound scoring methods. The development of LUNA involves synthetic and real data: We simulate synthetic data with an experimentally validated approach and scan ex vivo swine lungs as real data. Trained on abundant simulated data and fine-tuned with a small amount of real-world data, LUNA achieves robust performance, demonstrated by an aeration estimation error of 9% in ex-vivo lung scans. We demonstrate the potential of reconstructing lung aeration maps from RF data, providing a foundation for improving lung ultrasound reproducibility and diagnostic utility.

Many existing approaches to generalizing statistical inference amidst distribution shift operate under the covariate shift assumption, which posits that the conditional distribution of unobserved variables given observable ones is invariant across populations. However, recent empirical investigations have demonstrated that adjusting for shift in observed variables (covariate shift) is often insufficient for generalization. In other words, covariate shift does not typically ``explain away'' the distribution shift between settings. As such, addressing the unknown yet non-negligible shift in the unobserved variables given observed ones (conditional shift) is crucial for generalizable inference. In this paper, we present a series of empirical evidence from two large-scale multi-site replication studies to support a new role of covariate shift in ``predicting'' the strength of the unknown conditional shift. Analyzing 680 studies across 65 sites, we find that even though the conditional shift is non-negligible, its strength can often be bounded by that of the observable covariate shift. However, this pattern only emerges when the two sources of shifts are quantified by our proposed standardized, ``pivotal'' measures. We then interpret this phenomenon by connecting it to similar patterns that can be theoretically derived from a random distribution shift model. Finally, we demonstrate that exploiting the predictive role of covariate shift leads to reliable and efficient uncertainty quantification for target estimates in generalization tasks with partially observed data. Overall, our empirical and theoretical analyses suggest a new way to approach the problem of distributional shift, generalizability, and external validity.

Constructing atomic models from cryo-electron microscopy (cryo-EM) maps is a crucial yet intricate task in structural biology. While advancements in deep learning, such as convolutional neural networks (CNNs) and graph neural networks (GNNs), have spurred the development of sophisticated map-to-model tools like DeepTracer and ModelAngelo, their efficacy notably diminishes with low-resolution maps beyond 4 {\AA}. To address this shortfall, our research introduces DeepTracer-LowResEnhance, an innovative framework that synergizes a deep learning-enhanced map refinement technique with the power of AlphaFold. This methodology is designed to markedly improve the construction of models from low-resolution cryo-EM maps. DeepTracer-LowResEnhance was rigorously tested on a set of 37 protein cryo-EM maps, with resolutions ranging between 2.5 to 8.4 {\AA}, including 22 maps with resolutions lower than 4 {\AA}. The outcomes were compelling, demonstrating that 95.5\% of the low-resolution maps exhibited a significant uptick in the count of total predicted residues. This denotes a pronounced improvement in atomic model building for low-resolution maps. Additionally, a comparative analysis alongside Phenix's auto-sharpening functionality delineates DeepTracer-LowResEnhance's superior capability in rendering more detailed and precise atomic models, thereby pushing the boundaries of current computational structural biology methodologies.

Theory of Mind (ToM) reasoning entails recognizing that other individuals possess their own intentions, emotions, and thoughts, which is vital for guiding one's own thought processes. Although large language models (LLMs) excel in tasks such as summarization, question answering, and translation, they still face challenges with ToM reasoning, especially in open-ended questions. Despite advancements, the extent to which LLMs truly understand ToM reasoning and how closely it aligns with human ToM reasoning remains inadequately explored in open-ended scenarios. Motivated by this gap, we assess the abilities of LLMs to perceive and integrate human intentions and emotions into their ToM reasoning processes within open-ended questions. Our study utilizes posts from Reddit's ChangeMyView platform, which demands nuanced social reasoning to craft persuasive responses. Our analysis, comparing semantic similarity and lexical overlap metrics between responses generated by humans and LLMs, reveals clear disparities in ToM reasoning capabilities in open-ended questions, with even the most advanced models showing notable limitations. To enhance LLM capabilities, we implement a prompt tuning method that incorporates human intentions and emotions, resulting in improvements in ToM reasoning performance. However, despite these improvements, the enhancement still falls short of fully achieving human-like reasoning. This research highlights the deficiencies in LLMs' social reasoning and demonstrates how integrating human intentions and emotions can boost their effectiveness.

The semantic segmentation of pelvic organs via MRI has important clinical significance. Recently, deep learning-enabled semantic segmentation has facilitated the three-dimensional geometric reconstruction of pelvic floor organs, providing clinicians with accurate and intuitive diagnostic results. However, the task of labeling pelvic floor MRI segmentation, typically performed by clinicians, is labor-intensive and costly, leading to a scarcity of labels. Insufficient segmentation labels limit the precise segmentation and reconstruction of pelvic floor organs. To address these issues, we propose a semi-supervised framework for pelvic organ segmentation. The implementation of this framework comprises two stages. In the first stage, it performs self-supervised pre-training using image restoration tasks. Subsequently, fine-tuning of the self-supervised model is performed, using labeled data to train the segmentation model. In the second stage, the self-supervised segmentation model is used to generate pseudo labels for unlabeled data. Ultimately, both labeled and unlabeled data are utilized in semi-supervised training. Upon evaluation, our method significantly enhances the performance in the semantic segmentation and geometric reconstruction of pelvic organs, Dice coefficient can increase by 2.65% averagely. Especially for organs that are difficult to segment, such as the uterus, the accuracy of semantic segmentation can be improved by up to 3.70%.

Convolutional Neural Networks (CNN) have been employed for displacement estimation in ultrasound elastography (USE). High-quality axial strains (derivative of the axial displacement in the axial direction) can be estimated by the proposed networks. In contrast to axial strain, lateral strain, which is highly required in Poisson's ratio imaging and elasticity reconstruction, has a poor quality. The main causes include low sampling frequency, limited motion, and lack of phase information in the lateral direction. Recently, physically inspired constraint in unsupervised regularized elastography (PICTURE) has been proposed. This method took into account the range of the feasible lateral strain defined by the rules of physics of motion and employed a regularization strategy to improve the lateral strains. Despite the substantial improvement, the regularization was only applied during the training; hence it did not guarantee during the test that the lateral strain is within the feasible range. Furthermore, only the feasible range was employed, other constraints such as incompressibility were not investigated. In this paper, we address these two issues and propose kPICTURE in which two iterative algorithms were infused into the network architecture in the form of known operators to ensure the lateral strain is within the feasible range and impose incompressibility during the test phase.

Spatial temporal mobility data collected by location-based services (LBS) [42] and other means such as Call Data Records (CDR), WiFi hotspots, smart watches, cars, etc. is very useful from a socio-economical perspective as it is at the heart of many useful applications (e.g., navigation, geo-located search, geo-located games) and it allows answering numerous societal research questions [51]. For example, Call Data Records have been successfully used to provide real-time traffic anomaly as well as event detection [90, 92], and a variety of mobility datasets have been used in shaping policies for urban communities [31] or epidemic management in the public health domain [80, 79]. From an individual-level perspective, users can benefit from personalized recommendations when they are encouraged to share their location data with third parties [22]. While there is no doubt about the usefulness of location-based applications, privacy concerns regarding the collection and sharing of individuals' mobility traces or aggregated flow of movements have prevented the data from being utilized to their full potential [87, 9, 53]. Indeed, various studies have shown that numerous threats are open if location data falls into the hands of inappropriate parties. These threats include re-identification [68], the inference of sensitive information about users [53, 94](e.g., their home and work locations, religious beliefs, political interests or sexual

Generative AI has made impressive strides in enabling users to create diverse and realistic visual content such as images, videos, and audio. However, training generative models on large centralized datasets can pose challenges in terms of data privacy, security, and accessibility. Federated learning (FL) is an approach that uses decentralized techniques to collaboratively train a shared deep learning model while retaining the training data on individual edge devices to preserve data privacy. This paper proposes a novel method for training a Denoising Diffusion Probabilistic Model (DDPM) across multiple data sources using FL techniques. Diffusion models, a newly emerging generative model, show promising results in achieving superior quality images than Generative Adversarial Networks (GANs). Our proposed method Phoenix is an unconditional diffusion model that leverages strategies to improve the data diversity of generated samples even when trained on data with statistical heterogeneity or Non-IID (Non-Independent and Identically Distributed) data. We demonstrate how our approach outperforms the default diffusion model in an FL setting. These results indicate that high-quality samples can be generated by maintaining data diversity, preserving privacy, and reducing communication between data sources, offering exciting new possibilities in the field of generative AI.

Purpose: Trans-oral robotic surgery (TORS) using the da Vinci surgical robot is a new minimally-invasive surgery method to treat oropharyngeal tumors, but it is a challenging operation. Augmented reality (AR) based on intra-operative ultrasound (US) has the potential to enhance the visualization of the anatomy and cancerous tumors to provide additional tools for decision-making in surgery. Methods: We propose and carry out preliminary evaluations of a US-guided AR system for TORS, with the transducer placed on the neck for a transcervical view. Firstly, we perform a novel MRI-transcervical 3D US registration study. Secondly, we develop a US-robot calibration method with an optical tracker and an AR system to display the anatomy mesh model in the real-time endoscope images inside the surgeon console. Results: Our AR system reaches a mean projection error of 26.81 and 27.85 pixels for the projection from the US to stereo cameras in a water bath experiment. The average target registration error for MRI to 3D US is 8.90 mm for the 3D US transducer and 5.85 mm for freehand 3D US, and the average distance between the vessel centerlines is 2.32 mm. Conclusion: We demonstrate the first proof-of-concept transcervical US-guided AR system for TORS and the feasibility of trans-cervical 3D US-MRI registration. Our results show that trans-cervical 3D US is a promising technique for TORS image guidance.